The Impact of Brain Developmental Delay on the Learning Process During the Early Childhood Phase
DOI:
https://doi.org/10.64663/aet.56Keywords:
brain development, developmental delays, neural connectivity, synaptic pruning, neurodevelopmental disorders, educational therapyAbstract
This article investigates how early childhood learning processes are affected by delayed brain development. The crucial phases of brain development are discussed, along with the ways in which environmental and genetic variables can cause developmental delays. The prefrontal cortex (PFC) and hippocampus, two important learning brain regions, are examined in connection to language, motor, cognitive, and social-emotional development. The article explores the effects of neurodevelopmental disorders like as autism spectrum disorder (ASD) and attention deficit/hyperactive disorder (ADHD) in more detail and offers solutions for therapeutic assistance, early intervention, and educational approaches. The need of early diagnosis and intervention for the best learning results is emphasised in the work.
References
Amaral-Silva, L., Santin, J.M. Synaptic modifications transform neural networks to function without oxygen. BMC Biol 21, 54 (2023). https://doi.org/10.1186/s12915-023-01518-0
Araujo, D. M., Santos, D. C. C., & Lima, M. C. M. P. (2020). Cognitive, language and motor development of infants exposed to risk and protective factors. International Journal of Pediatric Otorhinolaryngology, 138. Article ID: 110353. https://doi.org/10.1016/j.ijporl.2020.110353
Chua, A. C. K., & Singh, H. s/o H.S. (2022). Psychoeducational diagnostic assessment, evaluation & profiling on children for educational therapists: A proposed procedure. Early Years Research, 2(1), 29-35.
Dayananda, K. K., Ahmed, S., Wang, D., Polis, B., Islam, R., & Kaffman, A. (2023). Early life stress impairs synaptic pruning in the developing hippocampus. Brain, Behaviour, and Immunity, 107, 16-31. https://doi.org/10.1016/j.bbi.2022.09.014
Farid, A., Maqbool, S., Ullah, E., Ali, A., & Farid, Z. (2020). Risk factors in children presenting with developmental delay. Pakistan Armed Forces Medical Journal, 70(3), 812-17.
Frazer, M. A., Cabrera, Y., Guthrie, R. S., & Poe, G. R. (2021). Shining a light on the mechanisms of sleep for memory consolidation. Current Sleep Medicine Reports, 7, 221-231. https://doi.org/10.1007/s40675-021-00204-3
Fitzgerald, E., Hor, K., & Drake, A. J. (2020). Maternal influences on fetal brain development: The role of nutrition, infection and stress, and the potential for intergenerational consequences. Early Human Development, 150. Article ID: 105190. https://doi.org/10.1016/j.earlhumdev.2020.105190
Ganguli, S., & Chavali, P. L. (2021). Intrauterine viral infections: impact of inflammation on fetal neurodevelopment. Frontiers in Neuroscience, 15. Article ID: 771557. https://doi.org/10.3389/fnins.2021.771557
González, L., Popovic, M., Rebagliato, M., Estarlich, M., Moirano, G., Barreto-Zarza, F., ... & Pizzi, C. (2024). Socioeconomic position, family context, and child cognitive development. European Journal of Pediatrics, 183(6), 2571-2585. https://doi.org/10.1007/s00431-024-05482-x
Grenier-Martin, J., & Rivard, M. (2022). Managing challenging behaviours at home without services: The perspective of parents having Young children with intellectual and developmental disability. Journal of Developmental and Physical Disabilities, 34(2), 373-397. https://doi.org/10.1007/s10882-021-09804-x n
Howard, L. M., & Khalifeh, H. (2020). Perinatal mental health: A review of progress and challenges. World Psychiatry, 19(3), 313-327. https://doi.org/10.1002/wps.20769
Iqubal, A., Ahmed, M., Ahmad, S., Sahoo, C. R., Iqubal, M. K., & Haque, S. E. (2020). Environmental neurotoxic pollutants: A review. Environmental Science and Pollution Research, 27, 41175-41198. https://doi.org/10.1007/s11356-020-10539-z
Jacobi, H., Faber, J., Timmann, D., & Klockgether, T. (2021). Update cerebellum and cognition. Journal of Neurology, 268, 3921-3925. https://doi.org/10.1007/s00415-021-10486-w
Jarrin, D. C., Awad, Y. A., Rowe, H., Noel, N. A., Ramil, J., & McGrath, J. J. (2020). Parental expectations are associated with children's sleep duration and sleep hygiene habits. Journal of Developmental & Behavioural Pediatrics, 41(7), 550-558. https://doi.org/10.1097/DBP.0000000000000818
Jiang, N., Xu, J., Li, X., Wang, Y., Zhuang, L., & Qin, S. (2021). Negative parenting affects adolescent internalizing symptoms through alterations in amygdala-prefrontal circuitry: A longitudinal twin study. Biological Psychiatry, 89(6), 560-569. https://doi.org/10.1016/j.biopsych.2020.08.002
Johnson, M. B., & Hyman, S. E. (2022). A critical perspective on the synaptic pruning hypothesis of schizophrenia pathogenesis. Biological Psychiatry, 92(6), 440-442. https://doi.org/10.1016/j.biopsych.2021.12.014
Hamdan, S., & Hallaq, E. (2021). Prolonged exposure to violence: Psychiatric symptoms and suicide risk among college students in the Palestinian territory. Psychological Trauma: Theory, Research, Practice, and Policy, 13(7), 772-782. https://doi.org/10.1037/tra0001043
Harikumar, A., Evans, D. W., Dougherty, C. C., Carpenter, K. L., & Michael, A. M. (2021). A review of the default mode network in autism spectrum disorders and attention deficit hyperactivity disorder. Brain Connectivity, 11(4), 253-263. https://doi.org/10.1089/brain.2020.0865
Hasan, F., Kalra, N., Siddique, N. A., Kumar, P., & Kumar, V. (2024). Broca's aphasia: A detailed review of its features, origins, diagnosis, and management. International Journal of Chemical Studies, 12(5), 8-14.
Havdahl, A., Wootton, R. E., Leppert, B., Riglin, L., Ask, H., Tesli, M., ... & Stergiakouli, E. (2022). Associations between pregnancy-related predisposing factors for offspring neurodevelopmental conditions and parental genetic liability to attention-deficit/hyperactivity disorder, autism, and schizophrenia: The Norwegian mother, father and child cohort study (MoBa). Journal of the American Medical Association (JAMA) Psychiatry, 79(8), 799-810. https://doi.org/10.1001/jamapsychiatry.2022.1728
Kautz‐Turnbull, C., & Petrenko, C. L. (2021). A meta‐analytic review of adaptive functioning in fetal alcohol spectrum disorders, and the effect of IQ, executive functioning, and age. Alcoholism: Clinical and Experimental Research, 45(12), 2430-2447. https://doi.org/10.1111/acer.14728
Khandelwal, N., Mandliya, J., Nigam, K., Patil, V., Mathur, A., & Pathak, A. (2020). Determinants of motor, language, cognitive, and global developmental delay in children with complicated severe acute malnutrition at the time of discharge: An observational study from Central India. PLoS One, 15(6). Article ID: e0233949. https://doi.org/10.1371/journal.pone.0233949
Keenan, H. T., Clark, A., Holubkov, R., & Ewing-Cobbs, L. (2023). Longitudinal developmental outcomes of infants and toddlers with traumatic brain injury. JAMA Network Open, 6(1). Article ID: e2251195. https://doi.org/10.1089/neu.2018.5687
Kiely, M. E., McCarthy, E. K., & Hennessy, Á. (2021). Iron, iodine and vitamin D deficiencies during pregnancy: epidemiology, risk factors and developmental impacts. Proceedings of the Nutrition Society, 80(3), 290-302. https://doi.org/10.1017/S0029665121001944
Knezevic, E., Nenic, K., Milanovic, V., & Knezevic, N. N. (2023). The role of cortisol in chronic stress, neurodegenerative diseases, and psychological disorders. Cells, 12(23). Article ID: 2726. https://doi.org/10.3390/cells12232726
Kolk, S. M., & Rakic, P. (2022). Development of prefrontal cortex. Neuropsychopharmacology, 47(1), 41-57. https://doi.org/10.1038/s41386-021-01137-9
Li, X., Lipschutz, R., Hernandez, S. M., Biekman, B., Shen, S., Montgomery, D. A., ... & Bick, J. (2021). Links between socioeconomic disadvantage, neural function, and working memory in early childhood. Developmental Psychobiology, 63(6). Article ID: e22181. https://doi.org/10.1002/dev.22181
Lipkin, P. H., Macias, M. M., Norwood, K. W., Brei, T. J., Davidson, L. F., Davis, B. E., ... & Voigt, R. G. (2020). Promoting optimal development: identifying infants and young children with developmental disorders through developmental surveillance and screening. Pediatrics, 145(1). Article ID: e20193449. https://doi.org/10.1542/peds.2019-3449
Lukito, S., Norman, L., Carlisi, C., Radua, J., Hart, H., Simonoff, E., & Rubia, K. (2020). Comparative meta-analyses of brain structural and functional abnormalities during cognitive control in attention-deficit/hyperactivity disorder and autism spectrum disorder. Psychological Medicine, 50(6), 894-919. https://doi.org/10.1017/s0033291720000574
Mackes, N. K., Golm, D., Sarkar, S., Kumsta, R., Rutter, M., Fairchild, G., ... & ERA Young Adult Follow-up team. (2020). Early childhood deprivation is associated with alterations in adult brain structure despite subsequent environmental enrichment. Proceedings of the National Academy of Sciences, 117(1), 641-649. https://doi.org/10.1073/pnas.1911264116
Malik-Soni, N., Shaker, A., Luck, H., Mullin, A. E., Wiley, R. E., Lewis, M. E., ... & Frazier, T. W. (2022). Tackling healthcare access barriers for individuals with autism from diagnosis to adulthood. Pediatric Research, 91(5), 1028-1035. https://doi.org/10.1038/s41390-021-01465-y
Martins, F., Oppolzer, D., Santos, C., Barroso, M., & Gallardo, E. (2019). Opioid use in pregnant women and neonatal abstinence syndrome: A review of the literature. Toxics, 7(1). Article No.: 9. https://doi.org/10.3390/toxics7010009
McDonald, S., & Genova, H. (2021). The effect of severe traumatic brain injury on social cognition, emotion regulation, and mood. Handbook of Clinical Neurology, 183, 235-260. https://doi.org/10.1016/B978-0-12-822290-4.00011-6
Mishra, A., Patni, P., Hegde, S., Aleya, L., & Tewari, D. (2021). Neuroplasticity and environment: A pharmacotherapeutic approach toward preclinical and clinical understanding. Current Opinion in Environmental Science & Health, 19. Article ID: 100210. https://doi.org/10.1016/j.coesh.2020.09.004
Morgan, C., Fetters, L., Adde, L., Badawi, N., Bancale, A., Boyd, R. N., ... & Novak, I. (2021). Early intervention for children aged 0 to 2 years with or at high risk of cerebral palsy: International clinical practice guideline based on systematic reviews. Journal of the American Medical Association (JAMA): Pediatrics, 175(8), 846-858. https://doi.org/10.1001/jamapediatrics.2021.0878
Mueller, I., & Tronick, E. (2020). The long shadow of violence: The impact of exposure to intimate partner violence in infancy and early childhood. International Journal of Applied Psychoanalytic Studies, 17(3), 232-245. https://doi.org//10.1002/aps.1668
Nelson, C. A., Frankeberger, J., & Chambers, C. D. (2024). An introduction to the HEALthy Brain and Child Development (HBCD) study. Developmental Cognitive Neuroscience, 69. Article ID: 101441. https://doi.org/10.1016/j.dcn.2024.101441
Nivens, C., Schwarz, E. B., Rodriguez, R., & Hoyt-Austin, A. (2024). Adverse childhood experiences and developmental delay in young US children. Maternal and Child Health Journal, 28(1), 5-10. https://doi.org/10.1007/s10995-023-03864-5
Parenteau, A. M., Alen, N. V., Deer, L. K., Nissen, A. T., Luck, A. T., & Hostinar, C. E. (2020). Parenting matters: Parents can reduce or amplify children's anxiety and cortisol responses to acute stress. Development and Psychopathology, 32(5), 1799-1809. https://doi.org/10.1017/S0954579420001285
Peters, W., Rice, S., Cohen, J., Murray, L., Schley, C., Alvarez-Jimenez, M., & Bendall, S. (2021). Trauma-focused cognitive–behavioural therapy (TF-CBT) for interpersonal trauma in transitional-aged youth. Psychological Trauma: Theory, Research, Practice, and Policy, 13(3), 313-321. https://doi.org/10.1037/tra0001016
Popova, S., Dozet, D., & Burd, L. (2020). Fetal alcohol spectrum disorder: can we change the future?. Alcoholism, Clinical and Experimental Research, 44(4), 815-819. https://doi.org/10.1111/acer.14317
Prigatano, G. P., Braga, L. W., Johnson, S. F., & Souza, L. M. (2021). Neuropsychological rehabilitation, neuroimaging and neuroplasticity: A clinical commentary. NeuroRehabilitation, 49(2), 255-265. https://doi.org/10.3233/NRE-218024
Scholl, C., Rule, M. E., & Hennig, M. H. (2021). The information theory of developmental pruning: Optimising global network architectures using local synaptic rules. PLoS Computational Biology, 17(10). Article ID: e1009458. https://doi.org/10.1371/journal.pcbi.1009458
Schurhoff, N., Toborek, M. Circadian rhythms in the blood–brain barrier: impact on neurological disorders and stress responses. Molecular Brain, 16, Article No.: 5. https://doi.org/10.1186/s13041-023-00997-0
Setijowati, E. D., Suprapti, H., Sugeng, M. W., & Wulandari, R. D. (2022). Chromosome aberration on growth and developmental disorder. Jurnal Kedokteran Brawijaya, 32(2), 104-110. https://doi.org/10.21776/ub.jkb.2022.032.02.5
Shonkoff, J. P. (2017). Breakthrough impacts: What science tells us about supporting early childhood development. Young Children, 72(2), 8-16. https://doi.org/10.17226/9824
Simon, K. C., Nadel, L., & Payne, J. D. (2022). The functions of sleep: A cognitive neuroscience perspective. Proceedings of the National Academy of Sciences of the United States of America, 119(44), e2201795119. https://doi.org/10.1073/pnas.2201795119
Spruyt, K. (2021). Neurocognitive effects of sleep disruption in children and adolescents. Child and Adolescent Psychiatric Clinics of North America, 30(1), 27-45. https://doi.org/10.1016/j.chc.2020.08.003
Steiner, P. (2020). Brain fuel utilization in the developing brain. Annals of Nutrition and Metabolism, 75(Suppl. 1), 8-18. https://doi.org/10.1159/000508054
Vandesande, S., Van Keer, I., Dhondt, A., & Maes, B. (2022). The social-emotional functioning of young children with a significant cognitive and motor developmental delay. International Journal of Developmental Disabilities, 68(4), 462-473. https://doi.org/10.1080/20473869.2020.1805574
Wang, H., Qin, C., Zhang, Y., & Fu, Y. (2020). Neural pruning via growing regularization. arXiv preprint arXiv:2012.09243. https://doi.org/10.48550/arXiv.2012.09243
Werlen, L., Gjukaj, D., Mohler-Kuo, M., & Puhan, M. A. (2020). Interventions to improve children's access to mental health care: A systematic review and meta-analysis. Epidemiology and Psychiatric Sciences, 29. Article No.: e58. https://doi.org/10.1017/S2045796019000544
Westacott, L. J., & Wilkinson, L. S. (2022). Complement Dependent synaptic reorganisation during critical periods of brain development and risk for psychiatric disorder. Frontiers in Neuroscience, 16. Article ID: 840266. https://doi.org/10.3389/fnins.2022.840266
Willoughby, M. T., Magnus, B., Vernon-Feagans, L., Blair, C. B., & Family Life Project Investigators. (2017). Developmental delays in executive function from 3 to 5 years of age predict kindergarten academic readiness. Journal of Learning Disabilities, 50(4), 359–372. https://doi.org/10.1177/0022219415619754
Zhang, W., Li, D., Pang, N., Jiang, L., Li, B., Ye, F., ... & Yin, F. (2022). The second-tier status of fragile X syndrome testing for unexplained intellectual disability/global developmental delay in the era of next-generation sequencing. Frontiers in Pediatrics, 10. Article ID: 911805. https://doi.org/10.3389/fped.2022.911805
Zhong, B. L., Xu, Y. M., & Li, Y. (2022). Prevalence and unmet need for mental healthcare of major depressive disorder in community-dwelling Chinese people living with vision disability. Frontiers in Public Health, 10. Article ID: 900425. https://doi.org/10.3389/fpubh.2022.900425
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