Alimentary Management via Food Supplements for Young Children with Autism: A Review
DOI:
https://doi.org/10.64663/aet.61Keywords:
Mineral, Treatment, Vitamin, Autism Spectrum Disorder, Nutritional DeficiencyAbstract
The primary traits of autism spectrum disorder (ASD) consist of the inability to socialize, communicate and use imagination, and/or manifestations of stereotypical behavior. A disruption in the development of an autistic brain has been widely accepted in explaining the neurodevelopmental causes linked to ASD, but the association between the brain and the condition remains unclear. In this regard, a majority of young children with ASD have been observed to manifest gastrointestinal (GI) problems with a rise in intestinal permeability contributing to the pathogenesis of severity of ASD symptoms. According to Hsiao (2014), the GI abnormalities, given their reported prevalence and correlation with the severity of key ASD-related behavioral abnormalities and the development of autism-related endophenotypes (e.g., immune dysregulation, hyperserotonemia, and metabolic dysfunction) are of particular interest in this paper. This review discusses the GI pathologies seen in ASD individuals and the association of particular GI conditions with known deficiencies in vitamins and minerals. With emerging evidence for a gut-brain connection in ASD (van De Sande, van Buul, & Brouns, 2014), vitamins and minerals have been widely used in nutritional or dietary treatment for ASD.
References
Adams, J. B. (2015). Vitamin/mineral supplements for children and adults with autism. Vitamins & Minerals, 3(127), 2376-1318. https://doi.org/10.4172/2376-1318.1000127 DOI: https://doi.org/10.4172/2376-1318.1000127
Adams, J. B., Audhya, T., McDonough-Means, S., Rubin, R. A., Quig, D., Geis, E., Gehn, E., Loresto, M., Mitchell, J., Atwood, S., Barnhouse, S., & Lee, W. (2011a). Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutrition & Metabolism, 8(1), 34. https://doi.org/10.1186/1743-7075-8-34 DOI: https://doi.org/10.1186/1743-7075-8-34
Adams, J. B., Audhya, T., McDonough-Means, S., Rubin, R. A., Quig, D., Geis, E., Gehn, E., Loresto, M., Mitchell, J., Atwood, S., Barnhouse, S., & Lee, W. (2011b). Effect of a vitamin/mineral supplement on children and adults with autism. BMC Pediatrics, 11, Article No. 111. https://doi.org/10.1186/1471-2431-11-111 DOI: https://doi.org/10.1186/1471-2431-11-111
Adams, J. B., & Holloway, C. (2004). Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder. Journal of Alternative and Complementary Medicine (New York, N.Y.), 10(6), 1033–1039. https://doi.org/10.1089/acm.2004.10.1033 DOI: https://doi.org/10.1089/acm.2004.10.1033
Adams, J. B., Kirby, J., Audhya, T., Whiteley, P., & Bain, J. (2022). Vitamin/mineral/micronutrient supplement for autism spectrum disorders: a research survey. BMC Pediatrics, 22(1), 590. https://doi.org/10.1186/s12887-022-03628-0 DOI: https://doi.org/10.1186/s12887-022-03628-0
Al-Farsi, Y. M., Waly, M. I., Deth, R. C., Al-Sharbati, M. M., Al-Shafaee, M., Al-Farsi, O., Al-Khaduri, M. M., Gupta, I., Ali, A., Al-Khalili, M., Al-Adawi, S., Hodgson, N. W., & Ouhtit, A. (2013). Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism. Nutrition (Burbank, Los Angeles County, Calif.), 29(3), 537-541. https://doi.org/10.1016/j.nut.2012.09.014 DOI: https://doi.org/10.1016/j.nut.2012.09.014
Alvarez, J. (2018, December 14). Autism risk factors identified in? dark matter? of human genome. Retrieved from: https://psych.ucsf.edu/news/autism-risk-factors-identified-‘dark-matter’-human-genome .
Amadi, C. N., Orish, C. N., Frazzoli, C., & Orisakwe, O. E. (2022). Dietary interventions for autism spectrum disorder: An updated systematic review of human studies. Psychiatrike = Psychiatriki, 33(3), 228–242. https://doi.org/10.22365/jpsych.2022.073 DOI: https://doi.org/10.22365/jpsych.2022.073
Amann, P. M., Eichmüller, S. B., Schmidt, J., & Bazhin, A. V. (2011). Regulation of gene expression by retinoids. Current Medicinal Chemistry, 18(9), 1405-12. https://doi.org/10.2174/092986711795029618 DOI: https://doi.org/10.2174/092986711795029618
Amaral, D. G. (2017, January 31). Examining the causes of autism. In Cerebrum: The Dana Forum on Brain Science. Dana Foundation. Retrieved from: https://dana.org/article/examining-the-causes-of-autism/ .
Amminger, G. P., Berger, G. E., Schäfer, M. R., Klier, C., Friedrich, M. H., & Feucht, M. (2007). Omega-3 fatty acids supplementation in children with autism: a double-blind randomized, placebo-controlled pilot study. Biological Psychiatry, 61(4), 551-553. https://doi.org/10.1016/j.biopsych.2006.05.007 DOI: https://doi.org/10.1016/j.biopsych.2006.05.007
An, J. Y., Lin, K., Zhu, L., Werling, D. M., Dong, S., Brand, H., Wang, H. Z., Zhao, X., Schwartz, G. B., Collins, R. L., Currall, B. B., Dastmalchi, C., Dea, J., Duhn, C., Gilson, M. C., Klei, L., Liang, L., Markenscoff-Papadimitriou, E., Pochareddy, S., Ahituv, N., … Sanders, S. J. (2018). Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder. Science (New York, N.Y.), 362(6420). Article ID: eaat6576. https://doi.org/10.1126/science.aat6576 DOI: https://doi.org/10.1126/science.aat6576
Asperger, H. (1944). Die “Autistischen Psychpathen” im Kindesalter. Archiv für Psychiatrie und Nervenkrankheiten, 117, 76-136. https://doi.org/10.1007/BF01837709 DOI: https://doi.org/10.1007/BF01837709
Autism Nutrition Research Center (2020). ANRC guidelines for comprehensive nutritional support. Retrieved from: https://www.autismnrc.org/assets/images/ANRC%20Product%20Images%202020/ANRC%20Guidelines%20-final%204-27-2020.pdf .
Babaknejad, N., Sayehmiri, F., Sayehmiri, K., Mohamadkhani, A., & Bahrami, S. (2016). The relationship between zinc levels and autism: Systematic Review and meta-analysis. Iranian Journal of Child Neurology, 10(4), 1-9. https://pubmed.ncbi.nlm.nih.gov/27843460/
Berbel, P., Navarro, D., & Román, G. C. (2014). An evo-devo approach to thyroid hormones in cerebral and cerebellar cortical development: etiological implications for autism. Frontiers in Endocrinology, 5, 146. https://doi.org/10.3389/fendo.2014.00146 DOI: https://doi.org/10.3389/fendo.2014.00146
Bhattacharya, P. T., Misra, S. R., & Hussain, M. (2016). Nutritional Aspects of Essential Trace Elements in Oral Health and Disease: An Extensive Review. Scientifica, 2016, 5464373. https://doi.org/10.1155/2016/5464373 DOI: https://doi.org/10.1155/2016/5464373
Bilgiç, A., Gürkan, K., Türkoğlu, S., Akça, Ö. F., Kılıç, B. G., & Uslu, R. (2010). Iron deficiency in preschool children with autistic spectrum disorders. Research in Autism Spectrum Disorders, 4(4), 639-644. https://doi.org/10.1016/j.rasd.2009.12.008 DOI: https://doi.org/10.1016/j.rasd.2009.12.008
Bjorklund G. (2013). The role of zinc and copper in autism spectrum disorders. Acta Neurobiologiae Experimentalis, 73(2), 225–236. https://doi.org/10.55782/ane-2013-1932 DOI: https://doi.org/10.55782/ane-2013-1932
Bjørklund, G., Waly, M. I., Al-Farsi, Y., Saad, K., Dadar, M., Rahman, M. M., Elhoufey, A., Chirumbolo, S., Jóźwik-Pruska, J., & Kałużna-Czaplińska, J. (2019). The Role of Vitamins in Autism Spectrum Disorder: What Do We Know?. Journal of Molecular Neuroscience : MN, 67(3), 373–387. https://doi.org/10.1007/s12031-018-1237-5 DOI: https://doi.org/10.1007/s12031-018-1237-5
Bleuler, P. E. (1911/1950). Dementia praecox or the group of schizophrenias [translated by Joseph Zinkin, pp. 63-68]. New York, NY: International Universities Press. Available on: https://archive.org/details/dementiapraecoxo0000bleu/page/n5/mode/2up
Bowles, J. T. (2017, April 13). Autism: New studies show direct link to vitamin D3 deficiency. Avialable on: https://jefftbowles.com/autism-vitamin-d3-deficiency-linked/#:~:text=Introduction%3A%20Folate%20is%20to%20spina%20bifida%20as%20Vitamin,help%20strengthen%20bone%20and%20teeth%20formation%20in%20babies .
Brennan, M. (2020, December 11). Everything you need to know about heme iron. Available on: https://www.activeiron.com/blog/everything-you-need-to-know-about-heme-iron/ .
Businaro, R. (2022). Food supplements to complement brain functioning. The benefits of a combination of magnesium, folic acid, omega-3 fatty acids and vitamin E. F1000Research, 11, 1-18. https://doi.org/10.12688/f1000research.75856.1 DOI: https://doi.org/10.12688/f1000research.75856.1
Camulli, J. E., & Goh, L. A. L. (2018). Re-conceptualizing autistic savantism as a spectrum syndromic disorder: A sequel to the case study of a young adult savant artist. European Journal of Special Education Research, 3(4), 185-204. http://dx.doi.org/10.46827/ejse.v0i0.1919 .
Cannell J. J. (2017). Vitamin D and autism, what's new?. Reviews in endocrine & metabolic disorders, 18(2), 183–193. https://doi.org/10.1007/s11154-017-9409-0 DOI: https://doi.org/10.1007/s11154-017-9409-0
Cashin, A., Sci, D. A., & Barker, P. (2009). The triad of impairment in autism revisited. Journal of Child & Adolescent Psychiatric Nursing, 22(4), 189-193. https://doi.org/10.1111/j.1744-6171.2009.00198.x DOI: https://doi.org/10.1111/j.1744-6171.2009.00198.x
Cheng, B., Zhu, J., Yang, T., Guo, M., Lai, X., Li, Q., ... & Li, T. (2021). Vitamin A deficiency increases the risk of gastrointestinal comorbidity and exacerbates core symptoms in children with autism spectrum disorder. Pediatric Research, 89(1), 211-216. https://doi.org/10.1038/s41390-020-0865-y DOI: https://doi.org/10.1038/s41390-020-0865-y
Chez, M. G., Buchanan, C. P., Aimonovitch, M. C., Becker, M., Schaefer, K., Black, C., & Komen, J. (2002). Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders. Journal of Child Neurology, 17(11), 833–837. https://doi.org/10.1177/08830738020170111501 DOI: https://doi.org/10.1177/08830738020170111501
Chia, K. H., Lim, B. H., & Lee, B. M. (2017). Chapter 2: Neuroimaging studies on the autistic brain: Praxiological implications for educational therapists. In A. Cost & E. Villalba (Eds.), Horizons in Neuroscience Research: Vol. 32 (pp. 79-128). Hauppauge, NY: Nova Science Publishers. https://doi.org/10.5281/zenodo.16959302
Cortesi, F., Giannotti, F., Sebastiani, T., Panunzi, S., & Valente, D. (2012). Controlled-release melatonin, singly and combined with cognitive behavioural therapy, for persistent insomnia in children with autism spectrum disorders: a randomized placebo-controlled trial. Journal of Sleep Research, 21(6), 700–709. https://doi.org/10.1111/j.1365-2869.2012.01021.x DOI: https://doi.org/10.1111/j.1365-2869.2012.01021.x
Courchesne, E., Redcay, E., & Kennedy, D. P. (2004). The autistic brain: birth through adulthood. Current Opinion in Neurology, 17(4), 489–496. https://doi.org/10.1097/01.wco.0000137542.14610.b4 DOI: https://doi.org/10.1097/01.wco.0000137542.14610.b4
Dhanjal, D. S., Bhardwaj, S., Chopra, C., Singh, R., Patocka, J., Plucar, B., ... & Kuca, K. (2022). Millennium nutrient N, N-dimethylglycine (DMG) and its effectiveness in autism spectrum disorders. Current Medicinal Chemistry, 29(15), 2632-2651. https://doi.org/10.2174/0929867328666211125091811 DOI: https://doi.org/10.2174/0929867328666211125091811
Daniells, S. (2009, August 20). Omega-3, vitamin E mix shows potential for autistic speech. Available on: https://www.nutraingredients.com/Article/2009/08/19/Omega-3-vitamin-E-mix-shows-potential-for-autistic-speech
DeSoto, M. C. (2016). Speculations on vitamin K, VKORC1 genotype and autism. Medical Hypotheses, 96, 30–33. https://doi.org/10.1016/j.mehy.2016.09.013 DOI: https://doi.org/10.1016/j.mehy.2016.09.013
D’Souza, S., & Renner, D. (2014). Not knowing: The art of turning uncertainty into opportunity. London, UK: LID Publishing Ltd. Available on: https://www.amazon.com/Not-Knowing-Turning-Uncertainty-Possibility/dp/1907794484
Dolske, M. C., Spollen, J., McKay, S., Lancashire, E., & Tolbert, L. (1993). A preliminary trial of ascorbic acid as supplemental therapy for autism. Progress in Neuro-psychopharmacology & Biological Psychiatry, 17(5), 765–774. https://doi.org/10.1016/0278-5846(93)90058-z DOI: https://doi.org/10.1016/0278-5846(93)90058-Z
Dosman, C. F., Drmic, I. E., Brian, J. A., Senthilselvan, A., Harford, M., Smith, R., & Roberts, S. W. (2006). Ferritin as an indicator of suspected iron deficiency in children with autism spectrum disorder: prevalence of low serum ferritin concentration. Developmental Medicine and Child Neurology, 48(12), 1008–1009. https://doi.org/10.1017/S0012162206232225 DOI: https://doi.org/10.1111/j.1469-8749.2006.tb01279.x
Dosman, C. F., Brian, J. A., Drmic, I. E., Senthilselvan, A., Harford, M. M., Smith, R. W., Sharieff, W., Zlotkin, S. H., Moldofsky, H., & Roberts, S. W. (2007). Children with autism: effect of iron supplementation on sleep and ferritin. Pediatric Neurology, 36(3), 152–158. https://doi.org/10.1016/j.pediatrneurol.2006.11.004 DOI: https://doi.org/10.1016/j.pediatrneurol.2006.11.004
Dufault, R., Schnoll, R., Lukiw, W. J., LeBlanc, B., Cornett, C., Patrick, L., ... & Crider, R. (2009). Mercury exposure, nutritional deficiencies and metabolic disruptions may affect learning in children. Behavioral and Brain Functions, 5(1), 1-15. https://doi.org/10.1186/1744-9081-5-44 DOI: https://doi.org/10.1186/1744-9081-5-44
Dunn, W. (1999). Sensory profile. San Antonio, TX: Psychological Corporation. Available on: https://archive.org/details/sensoryprofileus0000dunn
Duvall, M. G., Pikman, Y., Kantor, D. B., Ariagno, K., Summers, L., Sectish, T. C., & Mullen, M. P. (2013). Pulmonary hypertension associated with scurvy and vitamin deficiencies in an autistic child. Pediatrics, 132(6), e1699-e1703. https://doi.org/10.1542/peds.2012-3054 DOI: https://doi.org/10.1542/peds.2012-3054
El-Ansary, A., Bjørklund, G., Chirumbolo, S., & Alnakhli, O. M. (2017). Predictive value of selected biomarkers related to metabolism and oxidative stress in children with autism spectrum disorder. Metabolic Brain Disease, 32(4), 1209-1221. https://doi.org/10.1007/s11011-017-0029-x DOI: https://doi.org/10.1007/s11011-017-0029-x
Faber, S., Zinn, G. M., Kern, J. C., 2nd, & Kingston, H. M. (2009). The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders. Biomarkers: Biochemical indicators of exposure, response, and susceptibility to chemicals, 14(3), 171–180. https://doi.org/10.1080/13547500902783747 DOI: https://doi.org/10.1080/13547500902783747
Farrell, T., Rappaport, L., Sell, N., & Tang, B. (2011). Vitamin and exercise-based therapies. Developed for Autism Case Training: A Developmental-Behavioral Pediatrics Curriculum”. Available on: https://www.cdc.gov/ncbddd/actearly/autism/case-modules/pdf/treatments/Vitamin%20Dietary%20Supplements%20and%20Exercise-Based%20Therapies.pdf .
Fava, M., & Mischoulon, D. (2009). Folate in depression: efficacy, safety, differences in formulations, and clinical issues. The Journal of Clinical Psychiatry, 70 Suppl 5, 12–17. https://doi.org/10.4088/JCP.8157su1c.03 DOI: https://doi.org/10.4088/JCP.8157su1c.03
Feng, J., Shan, L., Du, L., Wang, B., Li, H., Wang, W., Wang, T., Dong, H., Yue, X., Xu, Z., Staal, W. G., & Jia, F. (2017). Clinical improvement following vitamin D3 supplementation in Autism Spectrum Disorder. Nutritional Neuroscience, 20(5), 284–290. https://doi.org/10.1080/1028415X.2015.1123847 DOI: https://doi.org/10.1080/1028415X.2015.1123847
Fraguas, R. Jr, Papakostas, G. I., Mischoulon, D., Bottiglieri, T., Alpert, J., & Fava, M. (2006). Anger attacks in major depressive disorder and serum levels of homocysteine. Biological Psychiatry, 60, 270-274. https://doi.org/10.1016/j.biopsych.2005.08.026 DOI: https://doi.org/10.1016/j.biopsych.2005.08.026
Freedman, B. (2018). Environmental science (6th edition). Halifax, Canada: Simple Book Publishing. Available on: https://books.google.com.sg/books/about/Environmental_Science.html?id=QbZswAEACAAJ&redir_esc=y
Frustaci, A., Neri, M., Cesario, A., Adams, J. B., Domenici, E., Dalla Bernardina, B., & Bonassi, S. (2012). Oxidative stress-related biomarkers in autism: systematic review and meta-analyses. Free Radical Biology & Medicine, 52(10), 2128–2141. https://doi.org/10.1016/j.freeradbiomed.2012.03.011 DOI: https://doi.org/10.1016/j.freeradbiomed.2012.03.011
Frye, R. E., Rose, S., Slattery, J., & MacFabe, D. F. (2015). Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome. Microbial Ecology in Health and Disease, 26, 27458. https://doi.org/10.3402/mehd.v26.27458 DOI: https://doi.org/10.3402/mehd.v26.27458
Frye, R. E., Slattery, J., Delhey, L., Furgerson, B., Strickland, T., Tippett, M., Sailey, A., Wynne, R., Rose, S., Melnyk, S., Jill James, S., Sequeira, J. M., & Quadros, E. V. (2018). Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial. Molecular Psychiatry, 23(2), 247–256. https://doi.org/10.1038/mp.2016.168 DOI: https://doi.org/10.1038/mp.2016.168
Frye, R. E., Slattery, J. C., & Quadros, E. V. (2017). Folate metabolism abnormalities in autism: potential biomarkers. Biomarkers in Medicine, 11(8), 687–699. https://doi.org/10.2217/bmm-2017-0109 DOI: https://doi.org/10.2217/bmm-2017-0109
Garcia, M. (2021, August 6). What is the triad of impairments? (With pictures). Available on: https://www.infobloom.com/what-is-the-triad-of-impairments.htm .
Gątarek, P., Jóźwik-Pruska, J., Bjørklund, G., Chirumbolo, S. & Kałużna-Czaplińska, J. (2020). Urinary carboxylic acids (UCAs) in subjects with autism spectrum disorder and their association with bacterial overgrowth. Reviews in Analytical Chemistry, 39(1), 78 -87. https://doi.org/10.1515/revac-2020-0109 DOI: https://doi.org/10.1515/revac-2020-0109
Gaugler, T., Klei, L., Sanders, S. J., Bodea, C. A., Goldberg, A. P., Lee, A. B., Mahajan, M., Manaa, D., Pawitan, Y., Reichert, J., Ripke, S., Sandin, S., Sklar, P., Svantesson, O., Reichenberg, A., Hultman, C. M., Devlin, B., Roeder, K., & Buxbaum, J. D. (2014). Most genetic risk for autism resides with common variation. Nature Genetics, 46(8), 881–885. https://doi.org/10.1038/ng.3039 DOI: https://doi.org/10.1038/ng.3039
Golnik, A. E., & Ireland, M. (2009). Complementary alternative medicine for children with autism: A physician survey. Journal of Autism and Developmental Disorders, 39(7), 996-1005. https://doi.org/10.1007/s10803-009-0714-7 DOI: https://doi.org/10.1007/s10803-009-0714-7
Gordon, I., Vander Wyk, B. C., Bennett, R. H., Cordeaux, C., Lucas, M. V., Eilbott, J. A., Zagoory-Sharon, O., Leckman, J. F., Feldman, R., & Pelphrey, K. A. (2013). Oxytocin enhances brain function in children with autism. Proceedings of the National Academy of Sciences of the United States of America, 110(52), 20953–20958. https://doi.org/10.1073/pnas.1312857110 DOI: https://doi.org/10.1073/pnas.1312857110
Gropper, S. S., & Smith, J. L. (2020). Advanced nutrition and human metabolism (7th ed.). Singapore: Cengage Learning Asia. Available on: https://prod.cengageasia.com/title/default/detail?isbn=9781305627857
Gumpricht, E., & Rockway, S. (2014). Can ω-3 fatty acids and tocotrienol-rich vitamin E reduce symptoms of neurodevelopmental disorders?. Nutrition (Burbank, Los Angeles County, Calif.), 30(7-8), 733–738. https://doi.org/10.1016/j.nut.2013.11.001 DOI: https://doi.org/10.1016/j.nut.2013.11.001
Gunes, S., Ekinci, O., & Celik, T. (2017). Iron deficiency parameters in autism spectrum disorder: clinical correlates and associated factors. Italian Journal of Pediatrics, 43(1), 86. https://doi.org/10.1186/s13052-017-0407-3 DOI: https://doi.org/10.1186/s13052-017-0407-3
Hallmayer, J., Cleveland, S., Torres, A., Phillips, J., Cohen, B., Torigoe, T., Miller, J., Fedele, A., Collins, J., Smith, K., Lotspeich, L., Croen, L. A., Ozonoff, S., Lajonchere, C., Grether, J. K., & Risch, N. (2011). Genetic heritability and shared environmental factors among twin pairs with autism. Archives of General Psychiatry, 68(11), 1095-1102. https://doi.org/10.1001/archgenpsychiatry.2011.76 DOI: https://doi.org/10.1001/archgenpsychiatry.2011.76
He, X., Liu, W., Tang, F., Chen, X., & Song, G. (2023). Effects of Probiotics on Autism Spectrum Disorder in Children: A Systematic Review and Meta-Analysis of Clinical Trials. Nutrients, 15(6), 1415. https://doi.org/10.3390/nu15061415 DOI: https://doi.org/10.3390/nu15061415
Hendren, R. L., James, S. J., Widjaja, F., Lawton, B., Rosenblatt, A., & Bent, S. (2016). Randomized, Placebo-Controlled Trial of Methyl B12 for Children with Autism. Journal of Child and Adolescent Psychopharmacology, 26(9), 774-783. https://doi.org/10.1089/cap.2015.0159 DOI: https://doi.org/10.1089/cap.2015.0159
Herndon, A. C., DiGuiseppi, C., Johnson, S. L., Leiferman, J., & Reynolds, A. (2009). Does nutritional intake differ between children with autism spectrum disorders and children with typical development?. Journal of Autism and Developmental Disorders, 39(2), 212-222. https://doi.org/10.1007/s10803-008-0606-2 DOI: https://doi.org/10.1007/s10803-008-0606-2
Heyneman C. A. (1996). Zinc deficiency and taste disorders. The Annals of Pharmacotherapy, 30(2), 186-187. https://doi.org/10.1177/106002809603000215 DOI: https://doi.org/10.1177/106002809603000215
Hsiao, E. Y. (2014). Gastrointestinal issues in autism spectrum disorder. Harvard Review of Psychiatry, 22(2), 104-111. https://doi.org/10.1097/HRP.0000000000000029 DOI: https://doi.org/10.1097/HRP.0000000000000029
Hyman, S. L., Levy, S. E., Myers, S. M., & Council on Children with Disabilities, Section on Developmental & Behavioral Pediatrics (2020). Identification, evaluation, and management of children with autism spectrum disorder. Pediatrics, 145(1). Article ID: e20193447. https://doi.org/10.1542/peds.2019-3447 DOI: https://doi.org/10.1542/9781610024716-part01-ch002
Hyman, S. L., Stewart, P. A., Schmidt, B., Cain, U., Lemcke, N., … & Ng, P. K. (2012). Nutrient intake from food in children with autism. Pediatrics, 130 Suppl 2(Suppl 2), S145–S153. https://doi.org/10.1542/peds.2012-0900L DOI: https://doi.org/10.1542/peds.2012-0900L
Iglesias-Vázquez, L., Van Ginkel Riba, G., Arija, V., & Canals, J. (2020). Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis. Nutrients, 12(3), 792. https://doi.org/10.3390/nu12030792 DOI: https://doi.org/10.3390/nu12030792
Indika, N.-L. R., Frye, R. E., Rossignol, D. A., Owens, S. C., Senarathne, U. D., Grabrucker, A. M., Perera, R., Engelen, M. P. K. J., & Deutz, N. E. P. (2023). The Rationale for Vitamin, Mineral, and Cofactor Treatment in the Precision Medical Care of Autism Spectrum Disorder. Journal of Personalized Medicine, 13(2), 252. https://doi.org/10.3390/jpm13020252 DOI: https://doi.org/10.3390/jpm13020252
IOM/FNB – Institute of Medicine, Food and Nutrition Board (2001). Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press. Available on: https://www.nationalacademies.org/read/10026/chapter/1
James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., & Neubrander, J. A. (2004). Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. The American Journal of Clinical Nutrition, 80(6), 1611-1617. https://doi.org/10.1093/ajcn/80.6.1611 DOI: https://doi.org/10.1093/ajcn/80.6.1611
James, S. J., Melnyk, S., Jernigan, S., Cleves, M. A., Halsted, C. H., … & Gaylor, D. W. (2006). Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: the official publication of the International Society of Psychiatric Genetics, 141B(8), 947-956. https://doi.org/10.1002/ajmg.b.30366 DOI: https://doi.org/10.1002/ajmg.b.30366
James, S. J., Melnyk, S., Fuchs, G., Reid, T., Jernigan, S., ... & Gaylor, D. W. (2009). Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. American Journal of Clinical Nutrition, 89(1), 425-430. https://doi.org/10.3945/ajcn.2008.26615 DOI: https://doi.org/10.3945/ajcn.2008.26615
Jiang, Y., Dang, W., Nie, H., Kong, X., Jiang, Z., & Guo, J. (2023). Omega-3 polyunsaturated fatty acids and/or vitamin D in autism spectrum disorders: a systematic review. Frontiers in psychiatry, 14, 1238973. https://doi.org/10.3389/fpsyt.2023.1238973 DOI: https://doi.org/10.3389/fpsyt.2023.1238973
Jick, H., & Kaye, J. A. (2003). Epidemiology and possible causes of autism. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 23(12), 1524-1530. https://doi.org/10.1592/phco.23.15.1524.31955 DOI: https://doi.org/10.1592/phco.23.15.1524.31955
Johnson, C. R., Handen, B. L., Mayer-Costa, M., & Sacco, K. (2008). Eating habits and dietary status in young children with autism. Journal of Developmental and Physical Disabilities, 20(5), 437-448. https://doi.org/10.1007/s10882-008-9111-y DOI: https://doi.org/10.1007/s10882-008-9111-y
Kałużna-Czaplińska J, Socha E, & Rynkowski J. B (2011). Vitamin supplementation reduces excretion of urinary dicarboxylic acids in autistic children. Nutrition Research, 31(7):497-502. https://doi.org/10.1016/j.nutres.2011.03.009 DOI: https://doi.org/10.1016/j.nutres.2011.06.002
Kanner, L. (1943). Autistic disturbances of affective contact. Nervous Child, 2(3), 217-250. Available on: https://dn721601.ca.archive.org/0/items/leo-kanner-autistic-affective-contact/leo-kanner-autistic-affective-contact_text.pdf
Kelley, J. L., Tobler, M., Beck, D., Sadler-Riggleman, I., Corey R. Quackenbush, C. R., Rodriguez, L. A., & Skinner, M. K. (2021). Epigenetic inheritance of DNA methylation changes in fish living in hydrogen sulfide–rich springs. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 118(26). Article ID: e2014929118. https://doi.org/10.1073/pnas.2014929118 DOI: https://doi.org/10.1073/pnas.2014929118
Kelly, G. (2019, May 21). What is CD38? An exploration of NAD+ consumption uses and functions of CD38. Available on: https://neurohacker.com/what-is-cd38-an-exploration-of-nad-consumption-uses-and-functions-of-cd38 .
Kittana, M., Ahmadani, A., Stojanovska, L., & Attlee, A. (2022). The role of Vitamin D supplementation in children with autism spectrum disorder: A narrative review. Nutrients, 14(1), 26. https://doi.org/10.3390/nu14010026 DOI: https://doi.org/10.3390/nu14010026
Lai, X., Zhang, Q., Zhu, J., Yang, T., Guo, M., ... & Li, T. Y. (2021). A weekly vitamin A supplementary program alleviates social impairment in Chinese children with autism spectrum disorders and vitamin A deficiency. European Journal of Clinical Nutrition, 75(7), 1118-1125. https://doi.org/10.1038/s41430-020-00827-9 DOI: https://doi.org/10.1038/s41430-020-00827-9
Landrigan, P. J. (2010). What causes autism? Exploring the environmental contribution. Current Opinion in Pediatrics, 22(2), 219-225. https://doi.org/10.1097/MOP.0b013e328336eb9a DOI: https://doi.org/10.1097/MOP.0b013e328336eb9a
Latif, A., Heinz, P., & Cook, R. (2002). Iron deficiency in autism and Asperger syndrome. Autism, 6(1), 103-114. https://doi.org/10.1177/1362361302006001008 DOI: https://doi.org/10.1177/1362361302006001008
Leitch, C. (2021, June 17). Fish adapted to toxins pass epigenetic changes onto offspring. Available on: https://www.labroots.com/trending/genetics-and-genomics/20689/fish-adapted-toxins-pass-epigenetic-changes-onto-offspring
Levy, S. E., Souders, M. C., Ittenbach, R. F., Giarelli, E., Mulberg, A. E., & Pinto-Martin, J. A. (2007). Relationship of dietary intake to gastrointestinal symptoms in children with autistic spectrum disorders. Biological Psychiatry, 61(4), 492-497. https://doi.org/10.1016/j.biopsych.2006.07.013 DOI: https://doi.org/10.1016/j.biopsych.2006.07.013
Lin, J. C., Chan, M. H., Lee, M. Y., Chen, Y. C., & Chen, H. H. (2016). N, N-dimethylglycine differentially modulates psychotomimetic and antidepressant-like effects of ketamine in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 71, 7-13. https://doi.org/10.1016/j.pnpbp.2016.06.002 DOI: https://doi.org/10.1016/j.pnpbp.2016.06.002
Lindsay, R. L., Eugene Arnold, L., Aman, M. G., Vitiello, B., Posey, D. J., McDougle, C. J., ... & Bozzolo, D. (2006). Dietary status and impact of risperidone on nutritional balance in children with autism: a pilot study. Journal of Intellectual and Developmental Disability, 31(4), 204-209. https://doi.org/10.1080/13668250601006924 DOI: https://doi.org/10.1080/13668250601006924
Liu, J., Liu, X., Xiong, X. Q., Yang, T., Cui, T., … Li, T. Y. (2017). Effects o vitamin A supplementation on gut microbiota in children with autism spectrum disorders: A pilot study. BMC Microbiology, 17. Article ID: 204. https://doi.org/10.1186/s12866-017-1096-1 DOI: https://doi.org/10.1186/s12866-017-1096-1
Lonsdale, D. (2004). Thiamine tetrahydrofurfuryldisulfide: A little known therapeutic agent. Medical Science Monitor, 10(9), RA199-RA203. PMID: 15328496 https://pubmed.ncbi.nlm.nih.gov/15328496/
Lonsdale, D., Shamberger, R. J., & Audhya, T. (2002). Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: A pilot study. Neuroendocrinology Letters, 23(4), 303-308. PMID: 12195231 https://pubmed.ncbi.nlm.nih.gov/12195231/
Lopez, P., Halary, S., & Bapteste, E. (2015). Highly divergent ancient gene families in metagenomic samples are compatible with additional divisions of life. Biology Direct, 10, Article No. 64. https://doi.org/10.1186/s13062-015-0092-3 DOI: https://doi.org/10.1186/s13062-015-0092-3
Madra, M., Ringel, R., & Margolis, K. G. (2020). Gastrointestinal Issues and Autism Spectrum Disorder. Child and Adolescent Psychiatric Clinics of North America, 29(3), 501-513. https://doi.org/10.1016/j.chc.2020.02.005 DOI: https://doi.org/10.1016/j.chc.2020.02.005
Malow, B. A., Findling, R. L., Schroder, C. M., Maras, A., Breddy, J., Nir, T., Zisapel, N., & Gringras, P. (2021). Sleep, Growth, and Puberty After 2 Years of Prolonged-Release Melatonin in Children With Autism Spectrum Disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 60(2), 252-261.e3. https://doi.org/10.1016/j.jaac.2019.12.007 DOI: https://doi.org/10.1016/j.jaac.2019.12.007
Marinov, D., Eyubova, S., Toneva, A., Chamova, R., Braykova, R., Hadzhieva, S., & Pancheva, R. (2025). Linking Dietary Patterns to Autism Severity and Developmental Outcomes: A Correlational Study Using Food Frequency Questionnaires; The Childhood Autism Rating Scale, Second Edition; And Developmental Profile 3. Biomedicines, 13(5), 1178. https://doi.org/10.3390/biomedicines13051178 DOI: https://doi.org/10.3390/biomedicines13051178
Martineau, J., Barthelemy, C., Garreau, B., & Lelord, G. (1985). Vitamin B6, magnesium, and combined B6-Mg: therapeutic effects in childhood autism. Biological Psychiatry, 20(5), 467-478. https://doi.org/10.1016/0006-3223(85)90019-8 DOI: https://doi.org/10.1016/0006-3223(85)90019-8
McGrane M. M. (2007). Vitamin A regulation of gene expression: molecular mechanism of a prototype gene. The Journal of Nutritional Biochemistry, 18(8), 497-508. https://doi.org/10.1016/j.jnutbio.2006.10.006 DOI: https://doi.org/10.1016/j.jnutbio.2006.10.006
McGinnis W. R. (2004). Oxidative stress in autism. Alternative therapies in health and medicine, 10(6), 22-92. PMID: 15624347 https://pubmed.ncbi.nlm.nih.gov/15624347/
Meguid, N., Zeidan, H., Hashish, A., Nasser, S., Hussein, F., Hemimi, M., & Nashaat, N. (2024). Efficacy of vitamin/mineral supplement on children with Down syndrome and autism spectrum disorder. International Journal of Developmental Disabilities, 1-10. https://doi.org/10.1080/20473869.2024.2438771 DOI: https://doi.org/10.1080/20473869.2024.2438771
Melillo, R. (2013). Autism: The Scientific Truth about Preventing, Diagnosing, and Treating Autism Spectrum Disorders--and what Parents Can Do Now. New York, NY: TarcherPerigee. Available on: https://www.amazon.sg/dp/0399159541?ref_=mr_referred_us_sg_sg
Melke, J., Goubran Botros, H., Chaste, P., Betancur, C., Nygren, G., Anckarsäter, H., Rastam, M., Ståhlberg, O., Gillberg, I. C., Delorme, R., Chabane, N., Mouren-Simeoni, M. C., Fauchereau, F., Durand, C. M., Chevalier, F., Drouot, X., Collet, C., Launay, J. M., Leboyer, M., Gillberg, C., … Bourgeron, T. (2008). Abnormal melatonin synthesis in autism spectrum disorders. Molecular psychiatry, 13(1), 90-98. https://doi.org/10.1038/sj.mp.4002016 DOI: https://doi.org/10.1038/sj.mp.4002016
Monteiro, M. A., Santos, A. A. A. D., Gomes, L. M. M., & Rito, R. V. V. F. (2020). Autism spectrum disorder: A systematic review about nutritional interventions. Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, 38. Article ID: e2018262. https://doi.org/10.1590/1984-0462/2020/38/2018262 DOI: https://doi.org/10.1590/1984-0462/2020/38/2018262
Moretti, P., Sahoo, T., Hyland, K., Bottiglieri, T., Peters, S., del Gaudio, D., Roa, B., Curry, S., Zhu, H., Finnell, R. H., Neul, J. L., Ramaekers, V. T., Blau, N., Bacino, C. A., Miller, G., & Scaglia, F. (2005). Cerebral folate deficiency with developmental delay, autism, and response to folinic acid. Neurology, 64(6), 1088-1090. https://doi.org/10.1212/01.WNL.0000154641.08211.B7 DOI: https://doi.org/10.1212/01.WNL.0000154641.08211.B7
Morris, C. R., & Agin, M. C. (2009). Syndrome of allergy, apraxia, and malabsorption: characterization of a neurodevelopmental phenotype that responds to omega 3 and vitamin E supplementation. Alternative Therapies in Health & Medicine, 15(4), 34. https://pubmed.ncbi.nlm.nih.gov/19623831/
Morris, M. S., Jacques, P. F., Rosenberg, I. H., & Selhub, J. (2007). Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. The American Journal of Clinical Nutrition, 85(1), 193-200. https://doi.org/10.1093/ajcn/85.1.193 DOI: https://doi.org/10.1093/ajcn/85.1.193
Navarro, F., Liu, Y., & Rhoads, J. M. (2016). Can probiotics benefit children with autism spectrum disorders?. World Journal of Gastroenterology, 22(46), 10093-10102. https://doi.org/10.3748/wjg.v22.i46.10093 DOI: https://doi.org/10.3748/wjg.v22.i46.10093
Nuttall J. R. (2017). The plausibility of maternal toxicant exposure and nutritional status as contributing factors to the risk of autism spectrum disorders. Nutritional Neuroscience, 20(4), 209-218. https://doi.org/10.1080/1028415X.2015.1103437 DOI: https://doi.org/10.1080/1028415X.2015.1103437
Nye, C., & Brice, A. (2005). Combined vitamin B6-magnesium treatment in autism spectrum disorder. The Cochrane Database of Systematic Reviews, 2005(4). Article ID: CD003497. https://doi.org/10.1002/14651858.CD003497.pub2 DOI: https://doi.org/10.1002/14651858.CD003497.pub2
Office of Dietary Supplements (2026). Dietary supplement fact sheets. National Institutes of Health. Available on: https://ods.od.nih.gov/factsheets/list-all/
Pangrazzi, L., Balasco, L., & Bozzi, Y. (2020). Natural antioxidants: A novel therapeutic approach to autism spectrum disorders?. Antioxidants (Basel, Switzerland), 9(12), 1186. https://doi.org/10.3390/antiox9121186 DOI: https://doi.org/10.3390/antiox9121186
Pineles, S. L., Avery, R. A., & Liu, G. T. (2010). Vitamin B12 optic neuropathy in autism. Pediatrics, 126(4), e967-e970. https://doi.org/10.1542/peds.2009-2975 DOI: https://doi.org/10.1542/peds.2009-2975
Pinto, D., Pagnamenta, A. T., Klei, L., Anney, R., Merico, D., Regan, R., ... & Yaspan, B. L. (2010). Functional impact of global rare copy number variation in autism spectrum disorders. Nature, 466(7304), 368-372. https://doi.org/10.1038/nature09146 DOI: https://doi.org/10.1038/nature09146
Prasad, A. S. (1995). Zinc: An overview. Nutrition, 11(1 Suppl), 93-99. PMID: 7749260 https://pubmed.ncbi.nlm.nih.gov/7749260/
Prasad, A. S., Beck, F. W., Grabowski, S. M., Kaplan, J., & Mathog, R. H. (1997). Zinc deficiency: changes in cytokine production and T-cell subpopulations in patients with head and neck cancer and in noncancer subjects. Proceedings of the Association of American Physicians, 109(1), 68-77. https://pubmed.ncbi.nlm.nih.gov/9010918/
Rafee, Y., Burrell, K., & Cederna-Meko, C. (2019). Lessons in early identification and treatment from a case of disabling vitamin C deficiency in a child with autism spectrum disorder. International Journal of Psychiatry in Medicine, 54(1), 64-73. https://doi.org/10.1177/0091217418791443 DOI: https://doi.org/10.1177/0091217418791443
Ramirez, D. (2020, December 18). Vegetarian health and nutrition: 7 Nutrients you can’t get from plants. Available on: https://veggie.news/2020-12-18-7-nutrients-you-cant-get-from-plants.html .
Ratajczak H. V. (2011). Theoretical aspects of autism: causes--a review. Journal of Immunotoxicology, 8(1), 68-79. https://doi.org/10.3109/1547691X.2010.545086 DOI: https://doi.org/10.3109/1547691X.2010.545086
Reynolds, A., Krebs, N. F., Stewart, P. A., Austin, H., Johnson, S. L., …. & Hyman, S. L. (2012). Iron status in children with autism spectrum disorder. Pediatrics, 130 Suppl 2(Suppl 2), S154–S159. https://doi.org/10.1542/peds.2012-0900M DOI: https://doi.org/10.1542/peds.2012-0900M
Reynolds, C. R., & Kamphaus, R. W. (2015). Behavior assessment system for children-Third Edition (BASC-3). Bloomington, MN: Pearson. Available on: https://www.pearsonclinical.com.au/en-au/Store/Professional-Assessments/Behaviour/Behaviour-Assessment-System-for-Children%2C-Third-Edition/p/P100010142
Riebold, M., Mankuta, D., Lerer, E., Israel, S., Zhong, S., Nemanov, L., … & Yaari, M. (2011). All-trans retinoic acid upregulates reduced CD38 transcription in lymphoblastoid cell lines from autism spectrum disorder. Molecular Medicine, 17, 799-806. https://doi.org/10.2119/molmed.2011.00080 DOI: https://doi.org/10.2119/molmed.2011.00080
Ross, A. C., Caballero, B., Cousins, R. J., Tucker, K. L., & Ziegler, T. R. (2012). Modern nutrition in health and disease (No. Ed. 11). Philadelphia, PA: Lippincott Williams & Wilkins. Available on: https://pure.psu.edu/en/publications/modern-nutrition-in-health-and-disease-eleventh-edition/ .
Ross, J. L. (2016). The dark matter of biology. Biophysical Journal, 111, 909-916. https://doi.org/10.1016/j.bpj.2016.07.037 DOI: https://doi.org/10.1016/j.bpj.2016.07.037
Rossignol, D. A., & Frye, R. E. (2014). Melatonin in autism spectrum disorders. Current Clinical Pharmacology, 9(4), 326-334. https://doi.org/10.2174/15748847113086660072 DOI: https://doi.org/10.2174/15748847113086660072
Saad, K., Abdel-Rahman, A. A., Elserogy, Y. M., Al-Atram, A. A., El-Houfey, A. A., … & Abdel-Salam, A. M. (2018). Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 59(1), 20-29. https://doi.org/10.1111/jcpp.12652 DOI: https://doi.org/10.1111/jcpp.12652
Sathe, N., Andrews, J. C., McPheeters, M. L., & Warren, Z. E. (2017). Nutritional and Dietary Interventions for Autism Spectrum Disorder: A Systematic Review. Pediatrics, 139(6), e20170346. https://doi.org/10.1542/peds.2017-0346 DOI: https://doi.org/10.1542/peds.2017-0346
Sayehmiri, F., Babaknejad, N., Bahrami, S., Sayehmiri, K., Daarabi, M., & Rezaei-Tavirani, M. (2015). Zinc/calcium levels in the field of autism disorders: A systematic review and meta-analysis. Iranian Journal of Child Neurology, 9(4), 1-9. https://pmc.ncbi.nlm.nih.gov/articles/PMC4670971/
Serafim, S.D., Sant Anna, L.M., & Rover, M.R. (2025). Dietary supplements in the management of symptoms associated with autism spectrum disorder: A scoping review. Nutrition Reviews. Article ID: nuaf085. https://doi.org/10.1093/nutrit/nuaf085 DOI: https://doi.org/10.1093/nutrit/nuaf085
Sivamaruthi, B. S., Suganthy, N., Kesika, P., & Chaiyasut, C. (2020). The Role of Microbiome, Dietary Supplements, and Probiotics in Autism Spectrum Disorder. International journal of environmental research and public health, 17(8), 2647. https://doi.org/10.3390/ijerph17082647 DOI: https://doi.org/10.3390/ijerph17082647
Skalny, A. V., Skalnaya, M. G., Bjørklund, G., Gritsenko, V. A., Aaseth, J., & Tinkov, A. A. (2018). Selenium and autism spectrum disorder. In B. Michalke (ed.), Selenium (pp. 193-210). Cham, Switzerland: Springer. https://doi.org/10.1007/978-3-319-95390-8_10 DOI: https://doi.org/10.1007/978-3-319-95390-8_10
Smart, A., Westmacott, K. L., Crew, A., Doran, O., & Hart, J. P. (2019). An Electrocatalytic Screen-Printed Amperometric Sensor for the Selective Measurement of Thiamine (Vitamin B1) in Food Supplements. Biosensors, 9(3). Article ID: 98. https://doi.org/10.3390/bios9030098 DOI: https://doi.org/10.3390/bios9030098
van De Sande, M. M., van Buul, V. J., & Brouns, F. J. (2014). Autism and nutrition: the role of the gut-brain axis. Nutrition Research Reviews, 27(2), 199-214. https://doi.org/10.1017/S0954422414000110 DOI: https://doi.org/10.1017/S0954422414000110
vinh quốc Lu'o'ng, K., & Nguyễn, L. T. (2013). The beneficial role of vitamin D in obesity: possible genetic and cell signaling mechanisms. Nutrition journal, 12, 89. https://doi.org/10.1186/1475-2891-12-89 DOI: https://doi.org/10.1186/1475-2891-12-89
Wada, O. (2004). What are trace elements? Their deficiency and excess states. Japan Medical Association Journal, 47(8), 351-358. https://www.cabidigitallibrary.org/doi/full/10.5555/20043179284
Wass, S. (2011). Distortions and disconnections: disrupted brain connectivity in autism. Brain and Cognition, 75(1), 18-28. https://doi.org/10.1016/j.bandc.2010.10.005 DOI: https://doi.org/10.1016/j.bandc.2010.10.005
Willyard, C. (2021). How gut microbes could drive brain disorders. Nature, 590, 22-25. https://doi.org/10.1038/d41586-021-00260-3 DOI: https://doi.org/10.1038/d41586-021-00260-3
Wing, L., & Gould, J. (1979). Severe impairments of social interaction and associated abnormalities in children: epidemiology and classification. Journal of autism and developmental disorders, 9(1), 11–29. https://doi.org/10.1007/BF01531288 DOI: https://doi.org/10.1007/BF01531288
Wu, D., Wu, M., Halpern, A., Rusch, D. B., Yooseph, S., … & Eisen, J. A. (2011). Stalking the fourth domain in metagenomic data: searching for, discovering, and interpreting novel, deep branches in marker gene phylogenetic trees. PloS one, 6(3), e18011. https://doi.org/10.1371/journal.pone.0018011 DOI: https://doi.org/10.1371/journal.pone.0018011
Xie, G.H. (2021). Hypothalamic atrophy as a probable neuroprodrome to autism: A short review. Early Years Research, 1(1), 1-9. https://doi.org/10.5281/zenodo.15208606
Zhang, Y., Hodgson, N. W., Trivedi, M. S., Abdolmaleky, H. M., Fournier, M., ... & Deth, R. C. (2016). Decreased brain levels of vitamin B12 in aging, autism and schizophrenia. PloS One, 11(1). Article ID: e0146797. https://doi.org/10.1371/journal.pone.0146797 DOI: https://doi.org/10.1371/journal.pone.0146797
Zhang, Z., Yu, L., Li, S., & Liu, J. (2018). Association Study of Polymorphisms in Genes Relevant to Vitamin B12 and Folate Metabolism with Childhood Autism Spectrum Disorder in a Han Chinese Population. Medical science monitor : international medical journal of experimental and clinical research, 24, 370–376. https://doi.org/10.12659/msm.905567 DOI: https://doi.org/10.12659/MSM.905567
Zikopoulos, B., & Barbas, H. (2013). Altered neural connectivity in excitatory and inhibitory cortical circuits in autism. Frontiers in Human Neuroscience, 7. Article ID: 609. https://doi.org/10.3389/fnhum.2013.00609 DOI: https://doi.org/10.3389/fnhum.2013.00609
Zhou, X., Reynolds, C., & Kamphaus, R. W. (2022). Diagnostic utility of Behavior Assessment System for Children-3 for children and adolescents with autism. Applied Neuropsychology: Child, 11(4), 647–651. https://doi.org/10.1080/21622965.2021.1929232 DOI: https://doi.org/10.1080/21622965.2021.1929232
Zhou, S. S., Zhou, Y. M., Li, D., & Ma, Q. (2013). Early infant exposure to excess multivitamin: a risk factor for autism? Autism Research and Treatment. Article ID: 963697. https://doi.org/10.1155/2013/963697 DOI: https://doi.org/10.1155/2013/963697
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Guo-Hui Xie, Dr Boon Hock Lim, Joseph Ban Meng Lee

This work is licensed under a Creative Commons Attribution 4.0 International License.